The Role of Brain Glycogen In Supporting Physiological Function

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작성자 Elizbeth 작성일 25-07-30 17:55 조회 5 댓글 0

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I. Neurons and glia. J. Elec. Micro. Techol. Cater, H. L., Benham, C. D., and Sundstrom, L. E. (2001). Neuroprotective role of monocarboxylate transport during glucose deprivation in slice cultures of rat hippocampus. Cater, H. L., Chandratheva, A., Benham, C. D., Morrison, B., and Sundstrom, L. E. (2003). Lactate and glucose as power substrates during, and after, oxygen deprivation in rat hippocampal acute and cultured slices. Champe, P. C., and Harvey, R. A. (2008). Biochemistry. Baltimore, MD: Lippincott Williams & Wilkins. Choeiri, C., Staines, W., and Messier, C. (2002). Immunohistochemical localization and quantification of glucose transporters in the mouse brain. Choi, H. B., Gordon, G. R., Zhou, N., Tai, C., Rungta, GlucoGold R. L., Martinez, J., et al. 2012). Metabolic communication between astrocytes and neurons through bicarbonate-responsive soluble adenylyl cyclase. Clausen, T. (1992). Potassium and sodium transport and pH regulation. Can. J. Physiol. Pharmacol. Cryer, P. E. (2013). Mechanisms of hypoglycemia-related autonomic failure in diabetes. N. Engl. J. Med. Dalsgaard, M. K., Ogoh, S., Dawson, E. A., Yoshiga, C. C., Quistorff, B., and Secher, N. H. (2004). Cerebral carbohydrate value of bodily exertion in humans.

Resting Heart Rate - The number of occasions your coronary heart beats per minute if you end up relaxed and sitting still. Shin splints - A decrease leg harm where there's ache alongside the entrance of the shin which may lead to stress fractures. Singlet - The sleeveless high commonly worn by runners. Slow twitch - Type of muscle fiber which contracts slowly however can perform for a very long time. Split times - The time it takes to run a portion of the whole run/race. Stability - Balance; skill to remain upright. Stamina - Having the ability to run with good type for a protracted period of time. Stretching - Movements designed to increase a muscle’s flexibility. For instance, bending over and touching your toes. Second wind - Going from being drained to feeling sturdy once more. Strength training - Exercises carried out with added resistance; i.e. lifting weights. Tapering - Reducing training quantity and/or depth to permit for recovery; usually one tapers earlier than an vital race.

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Fatty acids and ketone bodies are preferentially utilized by skeletal muscle, thereby sparing glucose for cells that depend completely on it, particularly pink blood cells and neurons. However, after roughly 18 hours of fasting, or during intense and extended exercise, glycogen stores develop into inadequate. At this point, in the absence of carbohydrate intake, gluconeogenesis turns into crucial. Its significance is additional highlighted by the fact that blood glucose ranges under 2 mmol/L can lead to unconsciousness. Additionally, with out gluconeogenesis, pyruvate can be lost, lowering the body’s capacity to provide ATP via aerobic respiration, more than 10 ATP molecules per pyruvate oxidized, making its conservation important throughout energy stress. In greater animals, gluconeogenesis happens in the liver, kidney cortex, and enterocytes. Quantitatively, the liver is the key site, producing about 90% of synthesized glucose, followed by the kidney cortex with round 10%. The liver’s key role is basically attributable to its dimension; the truth is, on a wet weight basis, the kidney cortex produces extra glucose than the liver.

The wide occurrence of glycogen in skeletal muscles signifies that it is crucial in offering a mechanism by which ATP quickly may be produced in muscle cells, which show a high and quickly fluctuating vitality turnover. The responses of muscle glycogen to such perturbations as train and natural glycogen stabilizer eating regimen are very properly documented in research of people in addition to various animal fashions (Bergström et al. 1967; Jensen & Richter, 2012). In addition, it has been understood for greater than half a century that the flexibility of muscle to exercise is critically compromised when the glycogen store is reduced to low ranges, even when there may be an abundance of other fuel sources (Bergström et al. 1967). Thus, Hultman and co-workers demonstrated a strong correlation between muscle glycogen health formula content material and endurance capability during prolonged cycling train (Bergström et al. 1967) and an inability to continue such train when the glycogen stores have been exhausted (Hermansen et al.

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