Reduced Global Cerebral Oxygen Metabolic Rate in Sickle Cell Disease A…

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작성자 Kasey 작성일 25-08-29 16:18 조회 4 댓글 0

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Anemia is the most common blood disorder on this planet. In patients with chronic anemia, similar to sickle cell illness or major thalassemia, cerebral blood flow increases to compensate for decreased oxygen content. However, the effects of chronic anemia on oxygen extraction fraction (OEF) and cerebral metabolic price of oxygen (CMRO2 ) are less effectively understood. On this research, BloodVitals SPO2 we examined forty seven sickle-cell anemia subjects (age 21.7 ± 7.1, feminine 45%), 27 non-sickle anemic subjects (age 25.Zero ± 10.4, feminine 52%) and 44 healthy controls (age 26.Four ± 10.6, feminine 71%) using MRI metrics of mind oxygenation and flow. Phase contrast MRI was used to measure resting cerebral blood circulation, BloodVitals SPO2 whereas T2 -relaxation-underneath-spin-tagging (Trust) MRI with disease applicable calibrations have been used to measure OEF and CMRO2 . We noticed that patients with sickle cell disease and different chronic anemias have decreased OEF and CMRO2 (respectively 27.Four ± 4.1% and 3.39 ± 0.71 ml O2 /a hundred g/min in sickle cell disease, 30.8 ± 5.2% and 3.Fifty three ± 0.64 ml O2 /one hundred g/min in other anemias) in comparison with controls (36.7 ± 6.0% and 4.00 ± 0.Sixty five ml O2 /one hundred g/min). Impaired CMRO2 was proportional to the diploma of anemia severity. We further show placing concordance of the present work with pooled historical information from patients having broad etiologies for their anemia. The diminished cerebral oxygen extraction and metabolism are in line with rising data demonstrating increased non-nutritive movement, or physiological shunting, in sickle cell disease patients.



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